On October 2, 2025, the NFL will see a thrilling matchup as the San Francisco 49ers take on the Los Angeles Rams at SoFi Stadium in Inglewood, with kickoff scheduled for 8:15 PM.

Looking at their 2024 performance, the San Francisco 49ers led their division and ranked second in their conference with a solid 3-1-0 record, reflecting a winning percentage of 0.75. They managed to score 80 points against 75, netting a difference of 5 points.

On the other hand, the Los Angeles Rams held the third spot in their division and were sixth in their conference, also sporting a 3-1-0 record with a winning percentage of 0.75. They marked 100 points for and 81 against, resulting in a positive point differential of 19.

Details from the previous week’s games for both the San Francisco 49ers and the Los Angeles Rams are not available at this time.

Leaders on the field will include quarterbacks Brock Purdy for the 49ers and Matthew Stafford for the Rams, each set to guide their respective teams.

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Regarding betting odds, the Los Angeles Rams are favored at home with a point spread of -6.30 whereas the San Francisco 49ers are underdogs with a point spread of +7.10. The game’s over/under is set at 54.20, indicating expectations for a high-scoring affair. For outright wins, the odds stand at -302 for the Rams and +245 for the 49ers, showcasing the Rams as notable favorites in this contest.